Latest research suggests cell nucleus plays a role in ageing
Scientific research is increasingly pointing to the fact that the cell
nucleus plays an important part in the ageing process – a discovery that could
revolutionise anti-ageing treatments.
The study, which was conducted by scientists at the National Cancer Institute
(NCI) in the US, indicates that mutations in the nucleus structural protein
lamin A can cause premature ageing syndrome.
However the research team have discovered that reversing inhibition of a splice
contained in the lamin A protein can reverse the onset of mutations that often
lead to signs of ageing, suggesting that lamin A is implicated in physiological
Further more the study also found that the cells of people aged over 80 tended
to have specific problems that the nucleus of young children do not have,
leading to obvious signs of ageing such as graying hair and wrinkling.
What the scientists now intend to do is work on establishing the idea that the
normal ageing process is at least partly concerned with the decay of the
nucleus. The biggest challenge will also be discovering a means of blocking out
"If this really has a physiological role in normal elderly people then it's a
huge deal," David Sinclair, who heads up research into ageing at Harvard Medical
School in the US, told Nature.com.
Cosmetic and personal care companies are currently making huge investments into
the research and development of anti-ageing products. This falls in line with
the demands of an ageing and increasingly affluent population that wants to
maintain youthful and healthy looks.
This is now fuelling a multi-billion dollar industry that has triggered one of
the fastest growing segments in the personal care market. All this means that
any solution that shows promise in fighting signs of ageing is bound to make
ears prick up.
Currently nanotechnology is thought to hold great potential in the fight against
wrinkles, as it is believed that creating active anti-ageing ingredients in nano
molecular form can increase efficacy.
However, this most recent research into cell nucleus protein could help further
focus the development of technologies such nanotechnology-based active
ingredients to improve efficacy still further.
Researchers Tom Misteli and Paola Scaffidi from the NCI says that healthy cells
always make a trace amount of an aberrant form of lamin A, but that younger
cells can sense and eliminate it. A proliferation of aberrant cells, found in
older humans, causes the nucleus to wrinkle up, leading to physiological signs
The big challenge the research team and other scientists now face is to try and
find a means of blocking this proliferation.
According to Misteli pinpointing a solution to this means, "You can take these
old cells and make them young again."
There are already drugs on the market that effectively enable this process to be
carried out and animal experiments are currently being carried out to determine
SOURCE: Cosmetics Design Europe
Print this article